Traffic crashes at toll plazas in Hong Kong

Poisson regression was used to identify the significant contributory factors to traffic crashes at toll plaza areas in Hong Kong. Information on the crash incidences and traffic volume at the toll plaza areas of ten tolled roads in Hong Kong during 1998-2003 were obtained from the traffic accident database system and annual traffic census of the Transport Department of the Government of Hong Kong Special Administrative Region. These data, together with the geometric and operational characteristics, including toll plaza width, carriageway width, degree of road curvature, road gradient, and toll booth configuration, were incorporated into two aggregated crash predictive models for different traffic directions. The results revealed that the crash likelihood of inbound traffic was increased significantly with downward slope and the crash likelihood of outbound traffic increased with the degree of road curvature.published_or_final_versio

Acupuncture for insomnia

Although conventional non-pharmacological and pharmacological treatments for insomnia are effective in many people, alternative therapies such as acupuncture are widely practised. However, it remains unclear whether current evidence is rigorous enough to support acupuncture for the treatment of insomnia. To determine the efficacy and safety of acupuncture for insomnia. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, PsycINFO, Dissertation Abstracts International, CINAHL, AMED, the Traditional Chinese Medical Literature Analysis and Retrieval System (TCMLARS), the World Health Organization (WHO) Trials Portal (ICTRP) and relevant specialised registers of the Cochrane Collaboration in October 2011. We screened reference lists of all eligible reports and contacted trial authors and experts in the field. Randomised controlled trials evaluating any form of acupuncture for insomnia. They compared acupuncture with/without additional treatment against placebo or sham or no treatment or same additional treatment. We excluded trials that compared different acupuncture methods or acupuncture against other treatments. Two review authors independently extracted data and assessed risk of bias. We used odds ratio (OR) and mean difference for binary and continuous outcomes respectively. We combined data in meta-analyses where appropriate. Thirty-three trials were included. They recruited 2293 participants with insomnia, aged 15 to 98 years, some with medical conditions contributing to insomnia (stroke, end-stage renal disease, perimenopause, pregnancy, psychiatric diseases). They evaluated needle acupuncture, electroacupuncture, acupressure or magnetic acupressure.Compared with no treatment (two studies, 280 participants) or sham/placebo (two studies, 112 participants), acupressure resulted in more people with improvement in sleep quality (compared to no treatment: OR 13.08, 95% confidence interval (CI) 1.79 to 95.59; compared to sham/placebo: OR 6.62, 95% CI 1.78 to 24.55). However, when assuming that dropouts had a worse outcome in sensitivity analysis the beneficial effect of acupuncture was inconclusive. Compared with other treatment alone, acupuncture as an adjunct to other treatment might marginally increase the proportion of people with improved sleep quality (13 studies, 883 participants, OR 3.08, 95% CI 1.93 to 4.90). On subgroup analysis, only needle acupuncture but not electroacupuncture showed benefits. All trials had high risk of bias and were heterogeneous in the definition of insomnia, participant characteristics, acupoints and treatment regimen. The effect sizes were generally small with wide confidence intervals. Publication bias was likely present. Adverse effects were rarely reported and they were minor. Due to poor methodological quality, high levels of heterogeneity and publication bias, the current evidence is not sufficiently rigorous to support or refute acupuncture for treating insomnia. Larger high-quality clinical trials are required.link_to_subscribed_fulltex

Effect of YH0618 soup on chemotherapy-induced toxicity in patients with cancer who have completed chemotherapy: study protocol for a randomized controlled trial

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PDXML: extensible markup language for processor description

This paper introduces PD-XML, a meta-language for describing instruction processors in general and with an emphasis on embedded processors, with the specific aim of enabling their rapid prototyping, evaluation and eventual design and implementation. The proposed methodology is based on the extensible markup language XML widely used structured information exchange and collaboration. PDXML allows for both high-level and low-level architectural specifications required to support a toolchain for design space exploration. PD-XML consists of three intuitive entities, describing: (a) the storage components available in a design, (b) the instructions supported by an architecture, and (c) the resources afforded by the microarchitecture implementation. PD-XML is not specific to any one architecture, compiler or simulation environment and hence provides greater flexibility than related machine description methodologies. We demonstrate how PD-XML can be interfaced to to existing description methodologies and tool-flows. In particular, we show how PD-XML specifications can be translated into appropriate machine descriptions for the parametric HPL-PD VLIW processor and for the flexible instruction processor approach

Mechanism involved in genistein activation of insulin-like growth factor 1 receptor expression in human breast cancer cells

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Acupuncture for persistent insomnia associated with major depressive disorder: a randomised controlled trial

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Acupressure, reflexology, and auricular acupressure for insomnia: A systematic review of randomized controlled trials

Previous randomized controlled trials (RCTs) have shown that acupuncture may be efficacious for insomnia. Instead of needling, acupressure, reflexology, and auricular acupressure are procedures involving physical pressure on acupoints or reflex areas. These variants of acupuncture are gaining popularity, perhaps due to their non-invasive nature. A systematic review has therefore been conducted to examine their efficacy and safety for insomnia. Two independent researchers searched five English and 10 Chinese databases from inception to May 2010. Forty RCTs were identified for analysis. Only 10 studies used sham controls, four used double-blind design, nine studies scored three or more by the Jadad scale, and all had at least one domain with high risk of bias. Meta-analyses of the moderate-quality RCTs found that acupressure as monotherapy fared marginally better than sham control. Studies that compared auricular acupressure and sham control showed equivocal results. It was also found that acupressure, reflexology, or auricular acupressure as monotherapy or combined with routine care was significantly more efficacious than routine care or no treatment. Owing to the methodological limitations of the studies and equivocal results, the current evidence does not allow a clear conclusion on the benefits of acupressure, reflexology, and auricular acupressure for insomnia. © 2012 Elsevier B.V.postprin

Spacerless metal-manganite pseudo-spin-valve structure

Author name used in this publication: W. F. ChengAuthor name used in this publication: A. RuotoloAuthor name used in this publication: Y. K. ChanAuthor name used in this publication: K. H. WongAuthor name used in this publication: C. W. Leung2007-2008 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Properties of the bridge sampler with a focus on splitting the MCMC sample

Computation of normalizing constants is a fundamental mathematical problem in various disciplines, particularly in Bayesian model selection problems. A sampling-based technique known as bridge sampling (Meng and Wong in Stat Sin 6(4):831–860, 1996) has been found to produce accurate estimates of normalizing constants and is shown to possess good asymptotic properties. For small to moderate sample sizes (as in situations with limited computational resources), we demonstrate that the (optimal) bridge sampler produces biased estimates. Specifically, when one density (we denote as p2) is constructed to be close to the target density (we denote as p1) using method of moments, our simulation-based results indicate that the correlation-induced bias through the moment-matching procedure is non-negligible. More crucially, the bias amplifies as the dimensionality of the problem increases. Thus, a series of theoretical as well as empirical investigations is carried out to identify the nature and origin of the bias. We then examine the effect of sample size allocation on the accuracy of bridge sampling estimates and discovered that one possibility of reducing both the bias and standard error with a small increase in computational effort is by drawing extra samples from the moment-matched density p2 (which we assume easy to sample from), provided that the evaluation of p1 is not too expensive. We proceed to show how the simple adaptive approach we termed “splitting” manages to alleviate the correlation-induced bias at the expense of a higher standard error, irrespective of the dimensionality involved. We also slightly modified the strategy suggested by Wang et al. (Warp bridge sampling: the next generation, Preprint, 2019. arXiv:1609.07690) to address the issue of the increase in standard error due to splitting, which is later generalized to further improve the efficiency. We conclude the paper by offering our insights of the application of a combination of these adaptive methods to improve the accuracy of bridge sampling estimates in Bayesian applications (where posterior samples are typically expensive to generate) based on the preceding investigations, with an application to a practical example

Acceleration of generalized hypergeometric functions through precise remainder asymptotics

We express the asymptotics of the remainders of the partial sums {s_n} of the generalized hypergeometric function q+1_F_q through an inverse power series z^n n^l \sum_k c_k/n^k, where the exponent l and the asymptotic coefficients {c_k} may be recursively computed to any desired order from the hypergeometric parameters and argument. From this we derive a new series acceleration technique that can be applied to any such function, even with complex parameters and at the branch point z=1. For moderate parameters (up to approximately ten) a C implementation at fixed precision is very effective at computing these functions; for larger parameters an implementation in higher than machine precision would be needed. Even for larger parameters, however, our C implementation is able to correctly determine whether or not it has converged; and when it converges, its estimate of its error is accurate.Comment: 36 pages, 6 figures, LaTeX2e. Fixed sign error in Eq. (2.28), added several references, added comparison to other methods, and added discussion of recursion stabilit